80s Antibiotic Shows New Promise Against Resistant Bacteria

A Virgen Macarena Hospital study published in The Lancet validates the effectiveness and safety of temocillin as an alternative to carbapenems.

Petri dish with glowing bacterial culture under a microscope.
IA

Petri dish with glowing bacterial culture under a microscope.

A clinical trial coordinated by the Virgen Macarena University Hospital in Seville has demonstrated the effectiveness of temocillin, an antibiotic from the 1980s, for treating multidrug-resistant enterobacteria infections.

The research, published in the journal ‘The Lancet’, validates temocillin as a safe and effective alternative to carbapenems, last-resort drugs that are losing effectiveness due to increasing bacterial resistance.
The study, named Project Astarté, involved 29 hospitals and analyzed the response of 334 patients. Results were similar between those treated with temocillin and those treated with carbapenems, highlighting the potential of this 'forgotten' drug.
This finding is crucial given the rise in enterobacteria infections, bacteria that can cause severe gastrointestinal illnesses and have developed resistance to conventional treatments.
The research group, part of the CIBERINFEC at the Carlos III Health Institute, aims to reduce carbapenem use and identify new therapeutic options to combat multidrug-resistant bacteria.